Effect of abacavir, lamivudine and zidovudine on fertility in women has not yet been studied. With regard to zidovudine showed that its use among men is not affected by the number, morphology and motility. Pregnancy The safety of methyltrienolone and test cycle in women during pregnancy has not yet been studied. There are only experimental studies on the effect of abacavir, lamivudine and zidovudine to the development of the fetus in animals. Therefore, during pregnancy is prescribed only if the expected benefit to the mother outweighs the potential risk to the fetus. There is evidence of a slight transient increase in lactic acid concentration in the serum, possibly due to mitochondrial disorders in newborns and infants, which at the time of the mother pregnancy and perintalnom period taking nucleoside reverse transcriptase inhibitors.
The clinical significance of this is not currently installed. In methyltrienolone and test cycle addition, there are isolated reports of developmental delay, seizures and other neurological disorders. However, the causal relationship of these disorders with the action of nucleoside reverse transcriptase inhibitors during the prenatal and postnatal periods is not installed. These data do not cancel existing recommendations for antiretroviral treatment during pregnancy to prevent vertical transmission . Lactation specialists recommend women, when possible, avoid breastfeeding to prevent infection. The concentration of lamivudine and zidovudine in human breast milk is comparable to their concentration in the serum. It is assumed, though it is not shown that abacavir is also excreted in breast milk. Women taking Trizivir is not recommended to breastfeed.
Effects on ability to drive vehicles and mechanisms
Research influence Trizivir and its constituent active ingredients (abacavir, lamivudine and zidovudine) on the ability to drive vehicles and operate machinery have not been conducted. The pharmacological properties of the active ingredients do not allow to predict the effect of methyltrienolone and test cycle for these activities. When assessing a patient’s ability to drive vehicles and use machines should be considered his clinical condition and the whole range of adverse reactions .